Clinical Applications of the Limulus Amoebocyte Lysate Test
CRC Press, 1990 M08 15 - 192 páginas
The primary focus of this book is to present the various clinical applications of the Limulus amoebocyte lysate (LAL) test for the detection of Gram-negative bacterial endotoxins. Using the clinical syndrome approach, it presents information from leading authorities pertaining to endotoxemia, meningitis, bacteriuria, gonorrhea, pyogenic arthritis, otitis media, ocular infections, peritonitis and perforation in blunt abdominal trauma, allied medical applications including hemodialysis water testing, and veterinary applications. This volume includes discussions on such topics as bacterial endotoxins and their clinical significance, the horseshoe crab and the various methodologies used in the LAL test, and the role of the Food and Drug Administration in the regulation of the LAL test. This publication is an absolute must for every physician, medical student, nurse, pathologist, toxicologist, microbiologist, public health official, and laboratory technician, as well as everyone involved in the teaching, evaluation, management, and treatment of clinical situations involving Gram-negative bacteria.
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The American Horseshoe Crab Limulus polyphemus
Allied Medical Applications of the Limulus Amoebocyte Lysate Test
Veterinary Applications An Overview
activity Alan Amebocyte Lysate Test antibiotic automated bacteremia Bacterial Endotoxins bacterial meningitis bacteriuria biological blood cell cerebrospinal fluid chromogenic substrate Clin clinical coli contamination culture results Detection of Bacterial detection of endotoxin detection of Gram-negative diagnosis dilution disease endophthalmitis endotoxemia endotoxin concentrations endotoxin levels endpoint evaluation false-negative false-positive gel-clot gelation GNB per milliliter gonococcal gonococcal urethritis gonorrhea Gram stain Gram-negative bacterial meningitis Gram-negative bacteriuria Gram-positive hemodialysis horseshoe crab human incubation infection inhibitor Jorgensen keratitis laboratory LAL test LAL test results LAL-urine Levin Limulus Amebocyte Lysate Limulus test lipid lipopolysaccharide Liss lysate LAL membrane method Microbiol Microbiology middle ear Nachum negative ng/ml Novitsky ocular otitis media pathogens patients pg/ml plasma positive LAL test predictive value protein pyrogen-free quantitative rapid detection reaction reported samples screening sepsis septic serum shown Spagna synovial fluid Table therapy tumor necrosis factor turbidimetric urinary tract urine vials
Página 166 - PA, and Oser RS: Detection of endotoxin in human blood and demonstration of an inhibitor. J LAB CLIN MED 75: 903-911, 1970.