Bacterial Invasion of Host CellsRichard J. Lamont Cambridge University Press, 2004 M03 29 - 328 páginas This book concerns the intimate association between bacteria and host cells. Many bacterial pathogens are able to invade and survive within cells at mucosal membranes. Remarkably, the bacteria themselves orchestrate this process through the exploitation of host cellular signal transduction pathways. Intracellular invasion can lead to disruption of host tissue integrity and perturbation of the immune system. An understanding of the molecular basis of bacterial invasion and of host cell adaptation to intracellular bacteria will provide fundamental insights into the pathophysiology of bacteria and the cell biology of the host. The book details specific examples of bacteria that are masters of manipulation of eukaryotic cell signaling and relates these events to the broader context of host-pathogen interaction. Written by experts in the field, this book will be of interest to researchers and graduate students in microbiology, immunology, biochemistry, as well as molecular medicine and dentistry. |
Contenido
Shigella invasion 25 | |
To Yop or not to Yop 59 | |
The interactions of EPEC and EHEC with | |
Molecular ecology and cell biology of Legionella | |
Listeria monocytogenes invasion and intracellular growth 161 | |
The varying mechanism of pathogenesis | |
Group A streptococcal invasion of host cells 239 | |
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Términos y frases comunes
Abu Kwaik acid ActA actin Actinobacillus actinomycetemcomitans activity adherence adhesins adhesion Apicella apoptosis Arp2/3 complex bacterial bacterium binding Biol cell surface cellular complex Cossart cytoskeleton cytosol DeVinney disease domain dot/icm effector proteins encoded enterocolitica enteropathogenic Escherichia coli entry EPEC EPEC and EHEC epithelial cells Escherichia coli eukaryotic expression fibronectin Fives-Taylor function gonococcal gonorrhoeae GROUP A STREPTOCOCCAL GTPases host cell human Immun induced Infect inhibit integrins interaction intimin intracellular growth invasion of host kinase Legionella pneumophila Listeria monocytogenes macrophages mechanisms mediated membrane ruffling Meyer Microbiol microtubule molecular molecules Molmeret mutants N-WASP Neisseria neutrophils pathogenesis pathogens pathways periodontal phagocytic phagocytosis phagosome phosphorylation Podbielski porin PrfA protease receptor regulation replication response role Salmonella Sansonetti Sasakawa secretion system sequence serotype Shigella flexneri signaling strains streptococci Streptococcus pyogenes tissue translocation TTSS type III secretion typhimurium tyrosine uptake vacuole vinculin virulence factors vitro Yersinia YopE YopH YopP/J