Mechanisms in Blood Coagulation, Fibrinolysis and the Complement SystemCambridge University Press, 1991 - 467 páginas This book provides a comprehensive account of the proteins involved in blood coagulation, fibrinolysis and the complement system. A major section of the book is devoted to each of these three systems, with separate chapters dealing in detail with structural aspects and different functional processes. Topics covered in the blood coagulation section include the activation of factors IX and X and prothrombin, and the formation and stabilisation of fibrin. The fibrinolysis section includes the activation of plasminogen, the degradation of fibrin and the regulation of fibrinolysis. The complement system itself is covered in chapters dealing with classical activation, alternative activation, the lytic complex and the regulatory processes involved. In addition, one section deals with special topics, including the kinin system, signal peptides, haemostasis, and the evolution of protein structure. This volume will be of use to researchers and advanced students in the fields of haematology, immunology and clinical chemistry. |
Contenido
an introduction | 3 |
3 | 25 |
Activation of prothrombin | 54 |
Activations in the extrinsic pathway | 71 |
Formation and stabilisation of fibrin | 80 |
Regulation of blood coagulation | 104 |
Components of the fibrinolytic system | 131 |
Mechanisms in fibrinolysis | 149 |
Anaphylatoxins and anaphylatoxin inactivator | 233 |
The kinin system | 243 |
Signal peptides | 249 |
Coagulationactive surfaces in vivo | 259 |
The binding of proteins to coagulationactive surfaces | 265 |
Integrins | 283 |
Some evolutionary considerations | 295 |
Appendix | 302 |
Overview of the complement system | 163 |
Alternative activation of the complement system | 191 |
The lytic complex MAC | 201 |
Regulation processes in the complement system | 214 |
372 | |
463 | |
Otras ediciones - Ver todas
Mechanisms in Blood Coagulation, Fibrinolysis and the Complement System Torben Halkier Vista previa limitada - 1991 |
Mechanisms in Blood Coagulation, Fibrinolysis and the Complement System Torben Halkier,Halkier Torben Sin vista previa disponible - 1991 |
Mechanisms in Blood Coagulation, Fibrinolysis and the Complement System Torben Halkier Sin vista previa disponible - 2008 |
Términos y frases comunes
a-chain Acad acid sequence activation of factor amino amino-acid residues amino-acid sequence antithrombin binding Biochem Biochemistry Biol blood coagulation bovine factor C-terminal C3-convertase catalytic cDNA cDNA sequence cells Chem chromosome cleaved Clin cloning co-factor complement component complement system complex contains disulphide bonds enzyme exons factor IX factor VIII factor Xa fibrin fibrinogen fibronectin formation fragment function gene glycoprotein growth-factor domain heavy chain HMM-kininogen human complement human factor Immunol inactivation inhibition inhibitor interaction introns kringle light chain membrane molecular mass molecule murine N-bound carbohydrate Natl pathway peptide is outlined phospholipid plasma prekallikrein plasmin plasminogen activator platelets position of cleavage potential attachment sites Proc protein proteinase prothrombin receptor region SCR domains sequence of human serine signal peptide single-chained sites for N-bound ẞ chain structure subunit surface t-PA terminus thrombin thrombomodulin tissue factor urokinase VIIa VIIIa von Willebrand factor Willebrand factor